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Migraine with aura is associated with neuroinflammation, suggesting a potential link between cortical spreading depression (CSD) and glial activation, new research shows. Investigators used integrated whole-brain PET/MRI to compare migraineurs with aura to healthy control persons and found elevations in the standardized uptake value ratio (SUVR) — a marker of glial activation. Participants with migraine demonstrated SUVR elevations in areas associated with nociceptive processing as well as areas associated with CSD, suggesting that migraine with aura is associated with neuroimmune activation, especially through the possible connection between CSD and glial activation, which was previously observed only in animals. Full story

17 April