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The human body's 46 chromosomes contain genes that, when mutated, can cause disease. (National Cancer Institute/AP). Jay Konduros used to rush home several times a year after accidentally cutting or bumping himself. There he would inject himself with refrigerated blood-clotting factor to prevent internal bleeding and extensive bruising and swelling. “I was walking on eggshells all the time,” said the former aerospace engineer who has a blood disorder called hemophilia B. Then, last year, Konduros enrolled in a clinical trial, receiving an experimental gene therapy at Children's Hospital of Philadelphia. Almost immediately, he began producing the missing clotting factor. Several weeks later... Full story

7 December