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While decades of study of model organisms have revolutionized our understanding of the microbial world, the vast majority of human-associated microorganisms are still “wild”—they lack functional tools to enable their functional interrogation. Our research group is working to build generalizable approaches to discover and characterize the bacterial species, genes, and enzymes relevant to human disease, with a particular focus on the gut bacterial metabolism of non-antibiotic drugs and diet-derived compounds. I will discuss our initial efforts focused on Eggerthella lenta, a poorly-studied but prevalent human gut Actinobacterium thought to play a key role in metabolism and pathogenesis. These inter-disciplinary studies Full story

12 February